The alarm protein causing obesity
Noggin – the glikozilirovanny protein known still for the effect of suppression of a signaling of BMP at the expense of isolation of a receptor of BMP.
The American scientists from TheUniversityofAlabamaatBirmingham opened new property of this protein. It appeared that there is a mechanism, thanks to which noggin directly induces a differentiation of mesenchymal stem cells (MOSCOW TIME) in адипоциты (cages of a fatty fabric), regardless of the main adipogenny signals of C/EBP?, C/EBP? and PPAR-?.
Scientists consider that the possible mechanism caused by noggin protein адипогенеза is connected with influence of Pax-1 influencing a differentiation MOSCOW TIME.
Research on preklinichesky model of spontaneous obesity (mouse) and on patients with excess of normal weight of a body showed that obesity is connected with the raised maintenance of noggin.
The data obtained in work prove noggin role in a differentiation MOSCOW TIME in cages of a fatty fabric and its possible role in obesity development.
This opening can become a basis for development of new methods of fight against the obesity, allowing to supervise адипогенез by means of impact on noggin.
Materials of research are presented in the article SawantA, etal. Noggin is a novel inducer of mesenchymal stem cell adipogenesis: implications for bone health and obesity. J Biol Chem. 2012 Feb 20. [Epub ahead of print]